Chicago Cubs vs. St. Louis Cardinals Game Preview, Odds, and Pitching Matchup – September 28, 2025

Sunday, September 28th, 2025

St. Louis Cardinals at Chicago Cubs: Key Matchup at Wrigley Field

The Chicago Cubs take on the St. Louis Cardinals at Wrigley Field in a pivotal National League Central division clash. First pitch is scheduled for 2:20 PM CT, promising plenty of excitement as these rivals meet for the 13th time this season. The Cubs currently lead the season series 7-5 and enter the game with a strong 91-70 record, while the Cardinals stand at 78-83.

Weather

Today at Wrigley Field, expect mild fall weather with temperatures around 68°F under partly cloudy skies. There’s a minimal chance of precipitation, making rain delays unlikely. Light winds from the southwest at 8 mph should have little effect on gameplay, providing ideal conditions for baseball.

Pitching Probables

The Cardinals are set to start Kyle Leahy, who has impressed with a 4-2 record, a 3.18 ERA, a 1.26 WHIP, and 79 strikeouts. Opposing him will be Cubs right-hander Javier Assad, holding a 3-1 record, 4.26 ERA, 1.29 WHIP, and 17 strikeouts. This pitching matchup should provide an intriguing dynamic for both offenses.

Team Performances

The Cubs have thrived at home with a 49-31 record at Wrigley and boast a 73-27 mark when recording eight or more hits. Their overall performance this season places them second in the NL Central. The Cardinals, meanwhile, are 34-46 on the road and 54-15 in games where they score five or more runs. Consistency on offense will be key for St. Louis if they hope to leave Chicago with a win.

Top Performers

For the Cubs, Kyle Tucker has powered the lineup with 22 home runs, 87 walks, 73 RBI, and a .268 batting average. Ian Happ has been a recent spark, collecting 11 hits over his last 40 at-bats, including four doubles, a home run, and nine RBI. On the Cardinals' side, Brendan Donovan’s .287 average is backed by 32 doubles, 10 home runs, and 50 RBI, while Alec Burleson has been hot, going 15-for-38 with three doubles and a home run in his last 10 games.

Recent Trends

Over the last 10 games, the Cubs have a 4-6 record, batting .248 as a team and holding a 3.87 ERA. They have outscored their opponents by 13 runs in that span. The Cardinals are 5-5 in their last 10, batting .253 with a 4.30 ERA but have been outscored by six runs.

Injury Report

The Cubs are dealing with several injuries: Cade Horton (ribs, 15-Day IL), Owen Caissie (concussion, 7-Day IL), Ryan Brasier (groin, 15-Day IL), Miguel Amaya (ankle, 10-Day IL), and Justin Steele (elbow, 60-Day IL).

The Cardinals have Willson Contreras (shoulder, 10-Day IL), Masyn Winn (meniscus, 10-Day IL), and Zack Thompson (lat, 60-Day IL) sidelined as well.

In Summary

This NL Central battle between the St. Louis Cardinals and the Chicago Cubs promises a competitive afternoon at historic Wrigley Field. With strong pitching matchups, notable offensive contributors, and ideal weather conditions, fans can expect a closely fought contest. The Cubs aim to solidify their spot near the top of the division, while the Cardinals look for a late-season boost. Stay tuned for updates and top highlights from this classic rivalry game.

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