Chicago Cubs vs. St. Louis Cardinals MLB Game Preview | June 25, 2025

Wednesday, June 25th, 2025

The Chicago Cubs face off against the St. Louis Cardinals in an MLB game on Wednesday, June 25, 2025, at 6:45 PM CT. The game will take place in St. Louis.

The Cubs enter the contest with a 46-33 overall record, leading the NL Central division. The Cardinals hold a 44-36 record, placing them third in the NL Central. Chicago comes into the game having lost three straight.

Pitching Matchup

Left-hander Matthew Boyd is scheduled to pitch for the Cubs. Boyd has a 6-3 record with a 2.84 ERA and a 1.14 WHIP, striking out 79 batters this season.

The Cardinals are expected to start right-hander Erick Fedde. Fedde's record is 3-6 with a 3.54 ERA and a 1.30 WHIP. He has recorded 55 strikeouts.

Betting Information

According to odds, the Chicago Cubs are favored with a moneyline of -134. The St. Louis Cardinals are the underdogs at +113. The over/under for the game is set at 9 runs.

Team Notes

St. Louis has a strong home record this season, going 26-15 at home. The Cardinals are particularly effective when outhitting their opponents, boasting a 29-10 record in such games.

Chicago has a decent road record at 21-18. The Cubs offense ranks seventh in MLB with a .255 team batting average.

This matchup marks the third meeting between the Cubs and Cardinals this season.

Top Performers

For the Cardinals, Lars Nootbaar leads the team with 11 home runs and has a .388 slugging percentage. Alec Burleson has been hot recently, hitting .333 (14 for 42) with four home runs and 13 RBIs over the last 10 games.

Cubs shortstop Nico Hoerner is the team's leading hitter with a .294 batting average. He has accumulated 17 doubles, a triple, one home run, 15 walks, and 33 RBIs. Kyle Tucker has been productive in the last 10 games, going 14 for 36 with two home runs and five RBIs.

Recent Performance

In their last 10 games, the Cardinals have an 8-2 record with a .264 batting average and a 3.52 ERA, outscoring opponents by 25 runs.

The Cubs have struggled over their last 10 outings, holding a 4-6 record. They have a .246 batting average and a high 5.80 ERA, having been outscored by 15 runs.

Injuries

Cardinals Injuries:

Ivan Herrera is on the 10-Day IL with a hamstring injury. Zack Thompson is on the 60-Day IL with a lat injury.

Cubs Injuries:

Miguel Amaya is on the 10-Day IL with an oblique injury. Eli Morgan is on the 60-Day IL with an elbow injury. Shota Imanaga is on the 15-Day IL with a leg injury. Javier Assad is on the 60-Day IL with an oblique injury. Justin Steele is on the 60-Day IL with an elbow injury.

In summary

The Chicago Cubs (46-33) face the St. Louis Cardinals (44-36) on June 25, 2025, at 6:45 PM CT in St. Louis. Matthew Boyd (6-3, 2.84 ERA) is the projected starter for the Cubs, while Erick Fedde (3-6, 3.54 ERA) is expected to pitch for the Cardinals. The Cubs are favored. St. Louis is strong at home, and Chicago boasts a top-10 batting average. Lars Nootbaar and Alec Burleson are key hitters for St. Louis, while Nico Hoerner and Kyle Tucker lead the Cubs offense. The Cardinals have a dominant 8-2 record in their last 10 games, contrasting with the Cubs' 4-6 slump. Both teams have multiple players on the injured list.

MLB Schedules

Today's MLB Games

There are no baseball games today.

Tomorrow's MLB Games

There are no baseball games tomorrow.

Yesterday's MLB Games

There were no baseball games yesterday.