Chicago Cubs vs. St. Louis Cardinals: Preview, Odds, and Key Players for September 27, 2025 at Wrigley Field

Saturday, September 27th, 2025

St. Louis Cardinals vs. Chicago Cubs: September 27, 2025 Preview

The St. Louis Cardinals travel to Chicago to face the Cubs at Wrigley Field in a late-season NL Central matchup. The Cubs currently lead the season series 6-5 and are coming into this game after taking the opener. Both teams are aiming to finish the year strong as the Cubs fight to solidify their postseason positioning and the Cardinals look to play spoiler.

Pitching Matchup

The Cardinals will send Michael McGreevy (8-3, 4.35 ERA, 1.23 WHIP, 55 strikeouts) to the mound. Opposing him is Jameson Taillon (10-7, 3.78 ERA, 1.07 WHIP, 90 strikeouts) for the Cubs. Oddsmakers have the Cubs as favorites (-173) with an over/under of 9.5 runs for the contest.

Team Records & Trends

The Cubs enter this game second in the NL Central with a 90-70 overall record and a strong 48-31 home mark. Chicago has thrived at the plate, especially when hitting multiple home runs—posting a 46-17 record in such games.

The Cardinals are fourth in the division at 78-82 and have struggled on the road with a 34-45 record. However, St. Louis has been tough to beat when keeping the ball in the park, posting a 39-19 record in games where they did not allow a home run.

Key Players to Watch

For the Cubs, Nico Hoerner continues to be a consistent threat, batting .300 with 29 doubles, four triples, seven home runs, and 61 RBI this season. Matt Shaw has been hot lately, going 10 for 35 with two doubles, a triple, and two home runs in his last 10 games.

On the Cardinals' side, Alec Burleson boasts 26 doubles, two triples, and 18 home runs. Brendan Donovan has also surged recently, hitting 14 for 37 with seven doubles and a home run in the past 10 games.

Recent Form

In their last 10 games, the Cubs are 4-6 with a .257 batting average and a 3.66 team ERA, outscoring opponents by 12 runs. The Cardinals are 5-5 over their last 10, batting .260 with a 4.55 ERA and have been outscored by seven runs.

Injury Report

The Cubs are dealing with several injuries, including Cade Horton (day-to-day, back), Owen Caissie (7-Day IL, concussion), Ryan Brasier (15-Day IL, groin), Miguel Amaya (10-Day IL, ankle), and Justin Steele (60-Day IL, elbow).

The Cardinals are missing Willson Contreras (10-Day IL, shoulder), Masyn Winn (10-Day IL, meniscus), and Zack Thompson (60-Day IL, lat).

Weather

Today at Wrigley Field, expect pleasant baseball conditions with temperatures in the mid-70s under mostly sunny skies. There’s little to no chance of precipitation, and winds will be light out of the southwest at around 7 mph, making for an ideal day at the ballpark.

In summary

The matchup between the St. Louis Cardinals (78-82) and Chicago Cubs (90-70) at Wrigley Field promises excitement for fans and significant implications for the NL Central standings. With strong starting pitchers, impactful hitters like Nico Hoerner and Alec Burleson, and ideal weather conditions, this game is set to be a highlight of the weekend in Chicago. The Cubs aim to extend their series lead, while the Cardinals look to upset their rivals as the regular season winds down.

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