Chicago Cubs vs. White Sox: Crosstown Classic Game Preview (July 25, 2025)

Friday, July 25th, 2025

The Chicago White Sox are set to host their cross-town rivals, the Chicago Cubs, on Friday, July 25, 2025, in an exciting MLB matchup.

Game Information

The highly anticipated game is scheduled for 6:40 PM CT at Guaranteed Rate Field in Chicago. This will be the fourth meeting between the two Chicago clubs this season.

Team Standings and Records

Chicago Cubs

The Chicago Cubs enter the game with a strong overall record of 60-42, placing them second in the National League Central division. On the road, the Cubs have maintained a solid 27-23 record. They have demonstrated an ability to generate offense, boasting a 50-18 record in games where they accumulate eight or more hits.

Chicago White Sox

The Chicago White Sox hold a 37-66 overall record, ranking them fifth in the American League Central division. Their home record stands at 21-29. The White Sox have faced challenges in close contests, evidenced by an 8-23 record in games decided by a single run.

Pitching Matchup

Cubs Probable Starter: Shota Imanaga

Shota Imanaga is slated to take the mound for the Cubs. He comes into the game with an impressive 7-3 record, a 2.40 ERA, a 0.92 WHIP, and 53 strikeouts.

White Sox Probable Starter: Adrian Houser

Adrian Houser is expected to start for the White Sox. Houser holds a 5-2 record with a sparkling 1.89 ERA, a 1.23 WHIP, and 44 strikeouts.

Betting Odds

The Cubs are favored in this contest with odds of -187, while the White Sox are listed at +154. The over/under for total runs in the game is set at 8 1/2.

Players to Watch

Cubs Offensive Leaders

Pete Crow-Armstrong has been a power threat for the Cubs, leading the team with 27 home runs and slugging .560. Nico Hoerner has also been productive recently, going 12 for 40 with a triple and three RBI over the past 10 games.

White Sox Offensive Leaders

Miguel Vargas leads the White Sox with 12 home runs and a .402 slugging percentage. Luis Robert has been hot over the last 10 games, with 12 hits in 35 at-bats, including a double, two home runs, and nine RBI. Kyle Teel recently had a standout performance, recording four hits against the Rays.

Recent Form

White Sox Last 10 Games

The White Sox have a 6-4 record over their last 10 games. During this stretch, they have a .243 batting average, a 3.62 ERA, and have outscored their opponents by 20 runs.

Cubs Last 10 Games

The Cubs also boast a 6-4 record in their last 10 outings. They have a .256 batting average and a 4.04 ERA, with an even run differential over this period.

Injury Report

Chicago White Sox Injuries

The White Sox injury list includes Prelander Berroa (60-Day IL, elbow), Shane Smith (15-Day IL, ankle), Tim Elko (10-Day IL, knee), Ryan Noda (10-Day IL, quadricep), Jared Shuster (15-Day IL, hand), Ky Bush (60-Day IL, elbow), Miguel Castro (60-Day IL, knee), Martin Perez (60-Day IL, forearm), Drew Thorpe (60-Day IL, elbow), and Jesse Scholtens (60-Day IL, elbow).

Chicago Cubs Injuries

The Cubs are dealing with injuries to Porter Hodge (15-Day IL, shoulder), Jameson Taillon (15-Day IL, calf), Miguel Amaya (10-Day IL, oblique), Eli Morgan (60-Day IL, elbow), Javier Assad (60-Day IL, oblique), and Justin Steele (60-Day IL, elbow).

In summary

The Chicago Cubs (60-42) will face the Chicago White Sox (37-66) in a cross-town rivalry game on July 25, 2025, at 6:40 PM CT. Cubs’ Shota Imanaga (7-3, 2.40 ERA) is set to pitch against White Sox’s Adrian Houser (5-2, 1.89 ERA). The Cubs, leading the season series, are favored at -187, with the over/under at 8.5 runs. Key players include Pete Crow-Armstrong for the Cubs and Miguel Vargas for the White Sox. Both teams enter the game with a 6-4 record over their last 10 games, but the Cubs hold a significant advantage in overall season performance and road record.

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