Cubs vs. White Sox 2025: Crosstown Classic Game Preview & Odds

Saturday, July 26th, 2025

The Chicago Cubs (60-43, second in the NL Central) are set to face the Chicago White Sox (38-66, fifth in the AL Central) in an MLB interleague matchup on Saturday, July 26, 2025, at 6:10 PM local time in Chicago.

Pitching Matchup

Cubs Starter: Cade Horton

Cade Horton takes the mound for the Cubs with a season record of 3-3, boasting a 4.04 ERA and a 1.36 WHIP. He has recorded 47 strikeouts this season.

White Sox Starter: Aaron Civale

The White Sox will counter with Aaron Civale, who holds a 2-6 record with a 4.76 ERA and a 1.40 WHIP. Civale has accumulated 42 strikeouts so far this year.

Betting Information

The Chicago Cubs are favored in this contest with odds of -192, while the Chicago White Sox are listed as underdogs at +160. The over/under for total runs in the game is set at 9 1/2.

Team Insights & Recent Form

The Chicago White Sox enter this game following Edgar Quero's impressive four-hit performance on Friday. The White Sox hold a 38-66 overall record and are 22-29 in home games. They have shown strength when out-hitting opponents, with a 26-13 record in such games.

The Chicago Cubs come into the game with a solid 60-43 overall record and a strong road record of 27-24. They rank sixth in the majors with a team on-base percentage of .324.

Saturday's game marks the fifth meeting between these two crosstown rivals this season. The Cubs currently hold a 3-1 lead in the season series against the White Sox.

Key Players to Watch

Chicago White Sox Standouts

For the White Sox, Chase Meidroth has been a key offensive contributor, tallying 11 doubles and three home runs. Colson Montgomery has been in good form over the past 10 games, going 9 for 36 with two doubles and three home runs.

Chicago Cubs Standouts

Pete Crow-Armstrong leads the Cubs' offense with 27 home runs and boasts a slugging percentage of .556. Matt Shaw has been particularly hot recently, with 10 hits in 25 at-bats, including three home runs and seven RBI over the past 10 games.

Last 10 Games Performance

The White Sox have had a strong showing in their last 10 games, posting a 7-3 record with a .278 batting average and a 3.62 ERA. They have outscored their opponents by 29 runs during this stretch.

The Cubs have a 5-5 record over their last 10 games. During this period, they have a .246 batting average, a 5.11 ERA, and have been outscored by 14 runs.

Injury Report

White Sox Injuries

Luis Robert: day-to-day (groin)

Prelander Berroa: 60-Day IL (elbow)

Shane Smith: 15-Day IL (ankle)

Tim Elko: 10-Day IL (knee)

Ryan Noda: 10-Day IL (quadricep)

Jared Shuster: 15-Day IL (hand)

Ky Bush: 60-Day IL (elbow)

Miguel Castro: 60-Day IL (knee)

Martin Perez: 60-Day IL (forearm)

Drew Thorpe: 60-Day IL (elbow)

Jesse Scholtens: 60-Day IL (elbow)

Cubs Injuries

Porter Hodge: 15-Day IL (shoulder)

Jameson Taillon: 15-Day IL (calf)

Miguel Amaya: 10-Day IL (oblique)

Eli Morgan: 60-Day IL (elbow)

Javier Assad: 60-Day IL (oblique)

Justin Steele: 60-Day IL (elbow)

In summary

The Chicago Cubs will visit the Chicago White Sox on July 26, 2025, for an MLB interleague game. The Cubs, with a 60-43 record, are favored against the 38-66 White Sox, leading the season series 3-1. Key pitching matchups feature Cade Horton for the Cubs and Aaron Civale for the White Sox. The Cubs boast a strong road record and high on-base percentage, while the White Sox have recently shown improved form, particularly at home. Top performers include Pete Crow-Armstrong for the Cubs and Chase Meidroth for the White Sox. Injury reports show several players on the injured list for both Chicago baseball teams, impacting roster depth for this highly anticipated cross-town classic.

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