Milwaukee Brewers vs. St. Louis Cardinals: Game Preview, Odds, Pitching Matchup for September 19, 2025

Friday, September 19th, 2025

Milwaukee Brewers at St. Louis Cardinals: Game Preview and Analysis

The Milwaukee Brewers look to get back on track and end their three-game road losing streak as they face the St. Louis Cardinals at Busch Stadium. With Milwaukee leading the NL Central and St. Louis trailing behind in fourth place, this matchup could have significant implications as the regular season heads toward its climax.

Pitching Matchup

The Brewers will send Jacob Misiorowski (5-2, 4.35 ERA, 81 strikeouts) to the mound. Misiorowski has demonstrated solid command and efficiency in his starts this season. Opposing him for the Cardinals is Sonny Gray (13-8, 4.43 ERA, 187 strikeouts), a veteran known for his ability to handle high-pressure situations. With both teams eager for a win, expect a tightly contested battle on the mound.

Team Records and Trends

St. Louis boasts a 42-36 record at home, but overall they stand at 74-79. A key weakness for the Cardinals has been preventing home runs—they are only 35-61 in games where they allow at least one homer.

Milwaukee has been strong on the road, posting a 43-32 record away from home and holding a 94-59 overall mark. The Brewers have been particularly dangerous when their offense gets rolling, boasting a dominant 71-7 record in games where they score at least five runs.

This game marks the 11th meeting of the season between these two NL Central rivals, with the Brewers leading the season series 6-4.

Weather

At Busch Stadium today, expect clear skies and mild baseball weather with temperatures near 75°F. There’s little chance of precipitation, and winds will be light out of the west at around 6 mph—ideal conditions for a comfortable game on the field and in the stands.

Top Performers

For the Cardinals, Brendan Donovan has been a consistent contributor, batting .281 with 26 doubles, 10 home runs, and 47 RBI. Thomas Saggese has also been hot recently, going 13-for-39 with two doubles and a home run over the last 10 games.

The Brewers are led by Christian Yelich, who has slugged 29 home runs and carries an impressive .467 slugging percentage. Jackson Chourio has performed well lately, hitting 12-for-41 with two homers and seven RBI in his last 10 games.

Recent Performance

Cardinals (Last 10 games)

Record: 3-7
Batting Average: .225
ERA: 4.40
Run Differential: -17

Brewers (Last 10 games)

Record: 6-4
Batting Average: .292
ERA: 3.48
Run Differential: +22

Injuries

Cardinals:

Willson Contreras: 10-Day IL (shoulder)
Masyn Winn: 10-Day IL (meniscus)
Zack Thompson: 60-Day IL (lat)

Brewers:

Jose Quintana: 15-Day IL (calf)
Shelby Miller: 60-Day IL (elbow)
Logan Henderson: 60-Day IL (elbow)
Trevor Megill: 15-Day IL (flexor strain)
D.L. Hall: 15-Day IL (oblique)
Jordan Montgomery: 60-Day IL (elbow)
Garrett Mitchell: 60-Day IL (oblique)
Connor Thomas: 60-Day IL (elbow)

In summary

The Milwaukee Brewers will try to bounce back from their recent road struggles as they take on the St. Louis Cardinals at Busch Stadium. Milwaukee’s strong offense and solid pitching give them a clear edge, while the Cardinals will rely on home-field advantage and a standout performance from Sonny Gray. The weather conditions are perfect for baseball, setting the stage for an exciting NL Central showdown. For more on each team, visit the Milwaukee Brewers and St. Louis Cardinals official MLB pages.

MLB Schedules

Today's MLB Games

There are no baseball games today.

Tomorrow's MLB Games

There are no baseball games tomorrow.

Yesterday's MLB Games

There were no baseball games yesterday.