Padres at Cardinals: MLB Game Preview, Odds & Pitchers (July 25, 2025)

Friday, July 25th, 2025

San Diego Padres at St. Louis Cardinals – July 25, 2025

Game Information

San Diego Padres (55-48, second in the NL West) vs. St. Louis Cardinals (53-51, fourth in the NL Central)

St. Louis; Friday, 6:15 p.m. EDT

Pitching Matchup

Padres: Nick Pivetta (10-2, 2.81 ERA, 1.00 WHIP, 127 strikeouts)

Cardinals: Miles Mikolas (5-7, 5.20 ERA, 1.30 WHIP, 69 strikeouts)

Betting Odds

Padres -140, Cardinals +117; over/under is 8 1/2 runs

Game Outlook

The San Diego Padres look to end their three-game losing streak with a win against the St. Louis Cardinals.

Team Performance Trends

St. Louis has a 53-51 record overall and a 30-20 record in home games. The Cardinals have a 24-6 record in games when they hit at least two home runs.

San Diego has a 55-48 record overall and a 24-30 record on the road. The Padres have a 30-9 record in games when they did not give up a home run.

Matchup Notes

The teams meet Friday for the second time this season.

Key Players

Alec Burleson has 18 doubles, 12 home runs and 44 RBI for the Cardinals. Willson Contreras is 13 for 40 with six doubles and two home homes over the past 10 games.

Manny Machado has 24 doubles, 19 home runs and 63 RBI for the Padres. Jackson Merrill is 9 for 35 with two doubles, two home runs and seven RBI over the past 10 games.

Recent Form

Cardinals: 3-7, .269 batting average, 5.82 ERA, outscored by 20 runs

Padres: 5-5, .254 batting average, 3.14 ERA, outscored opponents by nine runs

Injury Report

Cardinals: Nolan Gorman: 10-Day IL (back), Lars Nootbaar: 10-Day IL (ribs), Zack Thompson: 60-Day IL (lat)

Padres: Michael King: 60-Day IL (shoulder), Jhony Brito: 60-Day IL (forearm), Joe Musgrove: 60-Day IL (elbow)

In summary

This MLB game preview focuses on the matchup between the San Diego Padres (55-48, second in NL West) and the St. Louis Cardinals (53-51, fourth in NL Central) on July 25, 2025, at 6:15 PM EDT in St. Louis. The Padres, aiming to break a three-game losing streak, will send Nick Pivetta (10-2, 2.81 ERA) to the mound against the Cardinals' Miles Mikolas (5-7, 5.20 ERA). Key players to watch include Alec Burleson and Willson Contreras for the Cardinals, and Manny Machado and Jackson Merrill for the Padres. The Padres currently hold a 5-5 record in their last 10 games, while the Cardinals are 3-7.

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