Pittsburgh Pirates at Milwaukee Brewers MLB Preview: Skenes vs Misiorowski (June 25, 2025)

Wednesday, June 25th, 2025

Pittsburgh Pirates at Milwaukee Brewers Preview: June 25, 2025

Milwaukee, WI

Wednesday, 1:10 p.m. CT (2:10 p.m. EDT)

Game Matchup

The Pittsburgh Pirates (32-49, fifth in the NL Central) face the Milwaukee Brewers (44-36, second in the NL Central) in Milwaukee.

Pitching Probables

Pittsburgh Pirates

Paul Skenes (4-6, 1.85 ERA, 0.88 WHIP, 106 strikeouts)

Milwaukee Brewers

Jacob Misiorowski (2-0, 1.64 ERA, 0.55 WHIP, 11 strikeouts)

Betting Odds

Pirates: -116

Brewers: -104

Over/Under: 6 1/2 runs

Game Context

Both the Milwaukee Brewers and the Pittsburgh Pirates are looking for a series win with a victory on Wednesday.

Milwaukee has a 44-36 record overall and a 24-16 record in home games. The Brewers have a 17-1 record in games when they hit two or more home runs.

Pittsburgh is 32-49 overall and 12-28 in road games. The Pirates have a 15-3 record in games when they scored five or more runs.

The matchup Wednesday is the seventh time these teams match up this season. The season series is tied 3-3.

Top Performers

Milwaukee Brewers

Sal Frelick leads the Brewers with a .295 batting average, and has nine doubles, three triples, four home runs, 21 walks and 31 RBI. Christian Yelich is 17 for 40 with two home runs and 15 RBI over the last 10 games.

Pittsburgh Pirates

Oneil Cruz leads the Pirates with 13 home runs while slugging .404. Nick Gonzales is 17 for 43 with three doubles, two home runs and seven RBI over the last 10 games.

Recent Performance

Milwaukee Brewers

7-3 in their last 10 games, .317 batting average, 4.25 ERA, outscored opponents by 24 runs.

Pittsburgh Pirates

3-7 in their last 10 games, .243 batting average, 4.75 ERA, outscored by 14 runs.

Injury Report

Milwaukee Brewers

Brandon Woodruff: 60-Day IL (shoulder)

Connor Thomas: 60-Day IL (elbow)

Blake Perkins: 60-Day IL (shin)

Garrett Mitchell: 10-Day IL (oblique)

Nestor Cortes: 60-Day IL (elbow)

Robert Gasser: 60-Day IL (elbow)

Pittsburgh Pirates

Oneil Cruz: day-to-day (undisclosed)

Ryan Borucki: 15-Day IL (back)

Endy Rodriguez: 60-Day IL (elbow)

Colin Holderman: 15-Day IL (thumb)

Enmanuel Valdez: 60-Day IL (shoulder)

Justin Lawrence: 60-Day IL (elbow)

Tim Mayza: 60-Day IL (shoulder)

Jared Jones: 60-Day IL (elbow)

Johan Oviedo: 60-Day IL (elbow)

In summary

This article previews the MLB game between the Pittsburgh Pirates and the Milwaukee Brewers on June 25, 2025, scheduled for 1:10 PM CT in Milwaukee. It highlights the pitching matchup featuring Paul Skenes for the Pirates and Jacob Misiorowski for the Brewers. The Brewers are second in the NL Central with a 44-36 record, while the Pirates are fifth at 32-49. Key players include Sal Frelick and Christian Yelich for Milwaukee, and Oneil Cruz and Nick Gonzales for Pittsburgh. The season series is currently tied 3-3. Betting odds favor the Pirates slightly, with an over/under of 6.5 runs. Recent performance shows the Brewers with a 7-3 record in their last 10 games compared to the Pirates' 3-7. Both teams have notable players on their injury lists.

Related Links

• Pittsburgh Pirates News & Updates
• Pittsburgh Pirates Schedule & Scores
• Milwaukee Brewers News & Updates
• Milwaukee Brewers Schedule & Scores
• MLB News