San Diego Padres at St. Louis Cardinals: July 27, 2025 MLB Game Preview, Odds

Sunday, July 27th, 2025

The San Diego Padres (56-49, second in the NL West) are set to face the St. Louis Cardinals (54-52, fourth in the NL Central) in an MLB game on July 27, 2025, at 1:15 PM. This matchup in St. Louis marks the fourth time these teams have met this season, with the Cardinals currently leading the four-game series 2-1.

Game Preview: Padres at Cardinals

Pitching Matchup

For the Padres, Stephen Kolek is projected to start. He holds a 3-5 record with a 4.28 ERA, a 1.32 WHIP, and 54 strikeouts this season.

The Cardinals will counter with Michael McGreevy on the mound. McGreevy enters the game with a 2-1 record, a 3.49 ERA, a 1.02 WHIP, and 17 strikeouts.

Betting Odds

The St. Louis Cardinals are favored at -132, while the San Diego Padres are listed at +110. The over/under for the game is set at 9 runs.

Team Insights

The St. Louis Cardinals hold a 31-21 record at home and a 54-52 record overall. They have been particularly effective when their offense clicks, boasting a 41-9 record in games where they score at least five runs.

The San Diego Padres come into the game with a 56-49 overall record and a 25-31 mark in road games. San Diego has shown strong hitting performance, with a 37-19 record in games where they record eight or more hits.

Key Players

Willson Contreras leads the Cardinals' offense with 14 home runs and a .455 slugging percentage. Masyn Winn has been a hot hitter recently, going 14 for 38 with two doubles and four RBI over the past 10 games.

Fernando Tatis Jr. is a key contributor for the Padres, with 16 doubles, two triples, 17 home runs, and 44 RBI while maintaining a .266 batting average. Luis Arraez has also been productive in the last 10 games, with 13 hits and three doubles in 40 at-bats.

Recent Form

Over their last 10 games, the Cardinals have a 4-6 record, with a .251 batting average and a 4.66 ERA, being outscored by 17 runs.

The Padres also have a 4-6 record in their last 10 outings, but with a .258 batting average and a strong 2.86 ERA, they have outscored opponents by five runs.

Injury Report

The Cardinals are currently dealing with several injuries, including Nolan Gorman (10-Day IL, back), Lars Nootbaar (10-Day IL, ribs), and Zack Thompson (60-Day IL, lat).

The Padres also have key players on the injured list, including Michael King (60-Day IL, shoulder), Jhony Brito (60-Day IL, forearm), and Joe Musgrove (60-Day IL, elbow).

In summary

The San Diego Padres visit the St. Louis Cardinals on July 27, 2025, at 1:15 PM, with the Cardinals holding a 2-1 lead in their current four-game series. Stephen Kolek is slated to pitch for the Padres against Michael McGreevy for the Cardinals. St. Louis has a strong home record and performs well when scoring five or more runs, while San Diego excels when recording at least eight hits. Key offensive players include Willson Contreras and Masyn Winn for the Cardinals, and Fernando Tatis Jr. and Luis Arraez for the Padres. Both teams are 4-6 in their last 10 games but the Padres have a significantly lower ERA during that stretch. Several notable players are sidelined for both clubs due to injury.

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