St. Louis Cardinals vs. Milwaukee Brewers: Game Preview, Odds, and Key Players for September 14, 2025

Sunday, September 14th, 2025

St. Louis Cardinals vs. Milwaukee Brewers: Key NL Central Showdown Set for September 14, 2025

The St. Louis Cardinals aim to break a six-game road losing streak as they travel to take on the division-leading Milwaukee Brewers at American Family Field. This matchup is crucial for both squads in the National League Central race, with the Brewers holding a commanding lead and the Cardinals seeking to climb back into postseason contention.

Pitching Probables

The Cardinals will send Miles Mikolas (7-10, 4.84 ERA, 1.32 WHIP, 88 strikeouts) to the mound, while the Brewers counter with Jose Quintana (11-6, 3.88 ERA, 1.28 WHIP, 87 strikeouts). Milwaukee enters the game as -180 favorites, while the Cardinals come in at +150, and the over/under is set at 9 runs.

Weather

Today's weather at American Family Field is mild and comfortable for baseball, with temperatures around the mid-70s°F. Skies are mostly clear, and there's little to no chance of precipitation, ensuring dry playing conditions. Winds are light, so they shouldn't significantly affect the game. Overall, it's an excellent day to enjoy baseball at the ballpark.

Head-to-Head and Home/Road Splits

Milwaukee boasts a 91-58 overall record and has been dominant at home, posting a 48-26 mark at American Family Field. The Brewers offense ranks sixth in the NL with a .408 slugging percentage. The Cardinals, meanwhile, have struggled on the road with a 31-43 record and sit at 72-77 overall. St. Louis excels when limiting power, compiling a 37-18 record in games when not allowing a home run. This will be the 10th meeting between the teams this season, with Milwaukee leading the season series 6-3.

Top Performers

Milwaukee Brewers

Christian Yelich is a key force, ranking second on the team with 46 extra-base hits (18 doubles, 28 home runs). Jake Bauers has been hot, going 11-for-28 with two doubles, two home runs, and eight RBIs in the last 10 games.

St. Louis Cardinals

Alec Burleson leads the Cardinals with a .283 batting average, adding 22 doubles, two triples, and 17 home runs. Thomas Saggese has been consistent, going 11-for-39 with four RBIs over the last 10 games.

Recent Team Performance

Over their last 10 games, the Brewers have posted a 6-4 record, hitting .279 with a 3.38 ERA, and have outscored opponents by 13 runs. The Cardinals are 4-6 in their last 10, batting just .221 with a 4.00 ERA, and have been outscored by 12 runs.

Injuries to Watch

Milwaukee Brewers

The Brewers’ injury list includes Nick Mears (back tightness), Shelby Miller (elbow), Logan Henderson (elbow), Trevor Megill (flexor strain), D.L. Hall (oblique), Jordan Montgomery (elbow), Garrett Mitchell (oblique), and Connor Thomas (elbow).

St. Louis Cardinals

The Cardinals are dealing with injuries to Masyn Winn (meniscus), Nolan Arenado (shoulder), and Zack Thompson (lat).

In summary

The St. Louis Cardinals face the Milwaukee Brewers in what could be a pivotal NL Central clash on September 14, 2025. With the Brewers demonstrating dominance at home and holding a substantial lead in the division, the Cardinals will look to upset the odds and regain momentum. Expect a well-matched pitching duel, strong offensive showings led by Christian Yelich and Alec Burleson, and ideal playing conditions for an exciting day of baseball in Milwaukee.

Related Links

• St. Louis Cardinals News & Updates
• St. Louis Cardinals Schedule & Scores
• Milwaukee Brewers News & Updates
• Milwaukee Brewers Schedule & Scores
• MLB News