Tigers at Pirates: Mize vs. Keller MLB Preview (July 22, 2025)

Tuesday, July 22nd, 2025

Detroit Tigers at Pittsburgh Pirates MLB Game Preview: July 22, 2025

The Detroit Tigers (60-41, first in the AL Central) are set to face the Pittsburgh Pirates (40-61, fifth in the NL Central) in an MLB showdown on Tuesday, July 22, 2025, at 5:40 PM in Pittsburgh. The Pirates currently lead the ongoing series 1-0, with the overall season matchup tied at 2-2 between these two clubs.

Pitching Matchup

The Tigers are expected to send right-hander Casey Mize (9-3, 3.15 ERA, 1.22 WHIP, 77 strikeouts) to the mound. For the Pirates, Mitch Keller (3-10, 3.48 ERA, 1.14 WHIP, 92 strikeouts) is projected to start.

Betting Odds

The Detroit Tigers are favored at -150, while the Pittsburgh Pirates are listed at +126. The over/under for total runs in the game is set at 8.

Team Insights

The Pirates hold a 27-24 record at home this season and are 40-61 overall. They have shown strength when their bats are hot, recording a 28-17 record in games where they accumulate eight or more hits.

The Tigers boast an impressive 60-41 overall record and are solid on the road with a 28-23 away game record. Detroit has been particularly effective when scoring, holding a 41-6 record in games where they put up five or more runs.

Key Players

For the Pittsburgh Pirates, Andrew McCutchen has been a consistent performer, hitting .256 with 15 doubles, eight home runs, and 31 RBI. Recently, Tommy Pham has been productive, going 11 for 35 with two doubles and two home runs over his last 10 games.

Leading the Detroit Tigers offense, Gleyber Torres is hitting .281 with nine home run, 54 walks, and 45 RBI. Colt Keith has also been contributing, with eight hits, two doubles, two home runs, and four RBI in his last 10 outings.

Recent Form

Both teams have struggled recently. The Pirates have a 2-8 record over their last 10 games, with a .220 batting average and a 6.13 ERA, being outscored by 33 runs. The Tigers also have a 3-7 record in their last 10 contests, posting a .209 batting average and a 5.48 ERA, while being outscored by 26 runs.

Injury Report

Pirates Injured List: Chase Shugart (knee), Ryan Borucki (back), Endy Rodriguez (elbow), Enmanuel Valdez (shoulder), Justin Lawrence (elbow), Tim Mayza (shoulder), Jared Jones (elbow), Johan Oviedo (elbow).

Tigers Injured List: Sean Guenther (hip), Sawyer Gipson-Long (neck), Kerry Carpenter (hamstring), Jackson Jobe (flexor), Jason Foley (shoulder), Alex Cobb (hip), Ty Madden (shoulder), Jose Urquidy (elbow), Alex Lange (lat).

In Summary

This Tuesday, July 22, 2025 MLB matchup features the AL Central-leading Detroit Tigers (60-41) visiting the Pittsburgh Pirates (40-61). The Pirates currently hold a 1-0 lead in the ongoing series. Pitching will feature Casey Mize for Detroit and Mitch Keller for Pittsburgh. Detroit is favored with an over/under of 8 runs. Both teams enter the game struggling in their last 10 outings, with the Tigers at 3-7 and the Pirates at 2-8. Key players like Gleyber Torres for the Tigers and Andrew McCutchen for the Pirates will be critical to their teams' success. Extensive injury lists for both squads may impact performance.

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