Chicago White Sox vs. New York Yankees Prediction, Odds & Preview: MLB Game at Yankee Stadium on September 24, 2025

Wednesday, September 24th, 2025

Chicago White Sox at New York Yankees Preview – September 24, 2025

The Chicago White Sox begin a challenging road matchup against the New York Yankees on Wednesday evening at Yankee Stadium. The White Sox look to snap their four-game road losing streak as they meet the Yankees for the sixth time this season, with New York currently leading the season series 4-1.

Matchup Overview

Chicago White Sox (58-99, fifth in the AL Central) vs. New York Yankees (89-68, second in the AL East).

First pitch is scheduled for 6:05 p.m. CDT (7:05 p.m. EDT).

The Yankees are strong favorites at home, with a -373 money line, while the White Sox come in at +293. The game’s over/under is set at 8 runs.

Pitching Probables

The White Sox will start Fraser Ellard (0-2, 4.50 ERA, 1.50 WHIP, 20 strikeouts), while the Yankees send out ace Max Fried (18-5, 2.92 ERA, 1.11 WHIP, 182 strikeouts).

Team Performance

The Yankees have excelled at home this season, boasting a 45-31 record at Yankee Stadium and maintaining an 89-68 overall mark. Their .331 on-base percentage ranks second in the American League, powering their offense throughout the year.

The White Sox have struggled on the road, posting a 25-51 record away from Chicago. Overall, their 58-99 record places them near the bottom of the AL Central, but the team has performed well in games where they out-hit opponents, holding a 40-20 record in those matchups.

Weather

Today at Yankee Stadium, expect comfortable baseball weather with temperatures around 72°F under mostly clear skies. There’s little to no chance of precipitation, and a light breeze from the northwest at 7 mph should have minimal impact on gameplay. Conditions are ideal for fans and players alike.

Top Performers

For the Yankees, Aaron Judge continues to lead the team with 29 doubles, two triples, and 49 home runs. Recent standout Ben Rice has gone 15 for 33 with five doubles and a home run over the past 10 games.

The White Sox are powered by Miguel Vargas, who has collected 32 doubles, two triples, 15 home runs, and 57 RBI. Andrew Benintendi is 5 for 27 with a double, two home runs, and seven RBI over his last 10 appearances.

Recent Form – Last 10 Games

The Yankees have enjoyed a 7-3 stretch, posting a .268 batting average and a 3.58 ERA, outscoring opponents by 16 runs. The White Sox, meanwhile, have struggled, going 1-9 with a .181 average, a 4.18 ERA, and being outscored by 18 runs.

Injuries

Yankees: Brent Headrick (forearm), Jonathan Loaisiga (back), Clarke Schmidt (forearm), Oswaldo Cabrera (ankle), Jake Cousins (elbow), Gerrit Cole (elbow) are all on the injured list.

White Sox: Andrew Benintendi (achilles), Martin Perez (shoulder), Bryan Hudson (back), Luis Robert (hamstring), Elvis Peguero (elbow), Prelander Berroa (elbow), Ky Bush (elbow), Miguel Castro (knee), Drew Thorpe (elbow) are currently sidelined.

In summary

The Chicago White Sox face the New York Yankees in a late-season matchup with contrasting momentum and records. The Yankees hold significant advantages in both pitching and overall team performance, while the White Sox aim to end a tough losing skid on the road. With ideal weather and top talent on display, Yankees fans at Yankee Stadium can expect a competitive and entertaining game. This matchup is part of the season series where New York leads 4-1, and both teams will look to showcase their best players as the regular season nears its conclusion.

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