Milwaukee Brewers vs. St. Louis Cardinals: Series Decider & Pitching Matchup Preview for September 21, 2025

Sunday, September 21st, 2025

Milwaukee Brewers vs. St. Louis Cardinals Game Preview: September 21, 2025

The Milwaukee Brewers (95-60, first in the NL Central) head to Busch Stadium to take on the St. Louis Cardinals (75-80, fourth in the NL Central) for a Sunday afternoon matchup. With the series tied, the winner of this game will clinch the three-game set and build valuable momentum heading into the final stretch of the Major League Baseball season.

Weather

Today at Busch Stadium, expect mostly sunny skies with temperatures around 78°F, ideal for baseball. There is little to no chance of precipitation, and winds will be light out of the southwest at 6-10 mph, creating great conditions for both players and fans.

Pitching Matchup

The Brewers will send Freddy Peralta (17-6, 2.65 ERA, 1.07 WHIP, 195 strikeouts) to the mound. He will face Cardinals starter Matthew Liberatore (7-12, 4.30 ERA, 1.31 WHIP, 116 strikeouts).

Milwaukee is currently favored in this matchup with odds of -138, while St. Louis comes in at +118. The over/under is set at 9 runs.

Team Performance

St. Louis holds a 75-80 overall record and performs well at home with a 43-37 mark. When scoring at least five runs, the Cardinals are 51-15 this season, showing their offensive potential.

The Brewers have a strong road presence, going 44-33 away from home, and boast a formidable 95-60 overall record. When they out-hit their opponents, Milwaukee has an impressive 67-14 record.

This is the 13th meeting between the two teams in the 2025 season, with the Brewers leading the season series 7-5.

Top Performers

For St. Louis, Lars Nootbaar has been a steady contributor with 23 doubles, a triple, 13 home runs, and 48 RBI. Catcher Ivan Herrera is on a hot streak, going 10-for-40 with a double and two home runs over his last 10 games.

On the Brewers side, Sal Frelick leads the team with a .294 batting average along with 20 doubles, three triples, and 12 home runs. Caleb Durbin has also been productive recently, going 14-for-36 with a home run and five RBI in his last 10 games.

Recent Form

The Cardinals have struggled in their last 10 games with a 3-7 record, a .254 team batting average, a 3.91 ERA, and have been outscored by 11 runs.

Milwaukee, on the other hand, has gone 6-4 over the same span, hitting .287 as a team with a 3.64 ERA, while outscoring opponents by 14 runs.

Injury Report

Cardinals: Willson Contreras (10-Day IL, shoulder), Masyn Winn (10-Day IL, meniscus), Zack Thompson (60-Day IL, lat)

Brewers: William Contreras (day-to-day, hand), Jose Quintana (15-Day IL, calf), Shelby Miller (60-Day IL, elbow), Logan Henderson (60-Day IL, elbow), Trevor Megill (15-Day IL, flexor strain), D.L. Hall (15-Day IL, oblique), Jordan Montgomery (60-Day IL, elbow), Garrett Mitchell (60-Day IL, oblique), Connor Thomas (60-Day IL, elbow)

In summary

The Sunday, September 21, 2025 matchup between the Milwaukee Brewers and St. Louis Cardinals features two division rivals with plenty on the line. Freddy Peralta and Matthew Liberatore headline the pitching battle, while both teams look to their top performers for a crucial win. With ideal weather conditions and the series on the line, fans can expect an exciting and competitive afternoon at Busch Stadium. Keep an eye on key injuries and recent form as both teams push toward their postseason goals.

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