St. Louis Cardinals at Chicago White Sox MLB Game Preview | June 17, 2025

Tuesday, June 17th, 2025

The St. Louis Cardinals and Chicago White Sox are set to begin a three-game series.

Game Details

St. Louis Cardinals (37-35, fourth in the NL Central) at Chicago White Sox (23-49, fifth in the AL Central)

Chicago; Tuesday, 7:40 p.m. EDT

Matchup Snapshot

The White Sox hold a 16-18 record at home this season, contributing to their 23-49 overall mark. Chicago has struggled when allowing home runs, posting a 13-35 record in such games.

The Cardinals enter with a 37-35 overall record and are 15-21 when playing on the road. St. Louis has been effective offensively, going 26-7 in games where they score at least five runs.

This game marks the first meeting between the two clubs this season.

Pitching Probables

Cardinals: Matthew Liberatore (3-6, 4.17 ERA, 1.19 WHIP, 62 strikeouts)

White Sox: Shane Smith (3-3, 2.37 ERA, 1.17 WHIP, 64 strikeouts)

Betting Information

Cardinals -155, White Sox +128; over/under is 8 1/2 runs

Top Performers

For the White Sox, Miguel Vargas leads the team with a .242 batting average, tallying 18 doubles, a triple, and 10 home runs. Edgar Quero has been productive recently, going 12 for 31 with six RBI over the past 10 games.

Nolan Arenado is a key contributor for the Cardinals, hitting .243 with 11 doubles, a triple, eight home runs, and 36 RBI. Alec Burleson has hit well over his last 10 games, recording 12 hits in 37 at-bats with three doubles.

Last 10 Games

White Sox: 4-6 record, .228 batting average, 3.67 ERA, outscored opponents by four runs.

Cardinals: 3-7 record, .243 batting average, 4.40 ERA, outscored by opponents by eight runs.

Injury Report

White Sox: Luis Robert (day-to-day, thumb), Jared Shuster (15-Day IL, hand), Fraser Ellard (60-Day IL, lat), Ky Bush (60-Day IL, elbow), Lenyn Sosa (10-Day IL, hip), Miguel Castro (60-Day IL, knee), Jonathan Cannon (15-Day IL, back), Martin Perez (60-Day IL, forearm), Drew Thorpe (60-Day IL, elbow), Prelander Berroa (60-Day IL, elbow), Jesse Scholtens (60-Day IL, elbow)

Cardinals: Zack Thompson (60-Day IL, lat)

In summary

The St. Louis Cardinals (37-35) visit the Chicago White Sox (23-49) on Tuesday, June 17, 2025, at 7:40 p.m. EDT to open a three-game series. Matthew Liberatore is the probable pitcher for the Cardinals, facing Shane Smith for the White Sox. The Cardinals are favored with -155 odds, while the White Sox are +128, and the over/under is 8 1/2 runs. Key players include Miguel Vargas for Chicago and Nolan Arenado for St. Louis. Both teams have struggled recently, with the White Sox going 4-6 and the Cardinals 3-7 in their last 10 games. The White Sox have a lengthy injury list.

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