St. Louis Cardinals vs Milwaukee Brewers Prediction, Odds, and Pitching Matchup for September 13, 2025

Saturday, September 13th, 2025

St. Louis Cardinals vs. Milwaukee Brewers Game Preview - September 13, 2025

The St. Louis Cardinals (72-76, fourth in the NL Central) travel to face the Milwaukee Brewers (90-58, first in the NL Central) at American Family Field in a key late-season matchup. The Brewers hold the advantage in the season series, leading 5-3 over the Cardinals. First pitch is scheduled for 7:15 PM local time.

Pitching Matchup

The Cardinals will send Sonny Gray (13-8, 4.45 ERA, 1.22 WHIP, 179 strikeouts) to the mound as he looks to snap St. Louis’s five-game road losing streak. The Brewers counter with rising star Jacob Misiorowski (5-2, 4.09 ERA, 1.09 WHIP, 77 strikeouts). Oddsmakers favor Milwaukee with a -168 line, while the over/under is set at 7.5 runs.

Team Performance Overview

Milwaukee has been dominant at home, holding a 47-26 record at American Family Field and 90-58 overall. The Brewers excel when keeping opponents in the park: they are 46-13 in games where they have not given up a home run.

St. Louis, meanwhile, sits at 31-42 on the road and 72-76 overall. The Cardinals are 45-13 in games when they out-hit their opponents, highlighting the importance of offensive production in their success.

Top Performers

For the Brewers, infielder Brice Turang is enjoying a standout season with 18 home runs, 56 walks, 74 RBIs and a strong .289 batting average. Rookie sensation Jackson Chourio is surging recently, going 12-for-39 with four doubles, two homers, and six RBIs over the last 10 games.

The Cardinals have received power from Alec Burleson (22 doubles, two triples, 17 home runs), while Lars Nootbaar has contributed 11 hits and two RBIs in his last 10 games.

Recent Form

Over their last 10 games, the Brewers have played .500 baseball with a 5-5 record, a .274 average, 3.83 ERA, and have outscored opponents by 10 runs. The Cardinals are 4-6 in their last 10, struggling offensively with a .212 average and a 4.30 ERA, being outscored by 19 runs.

Injuries

The Brewers are battling several injuries with Nick Mears (back tightness), Shelby Miller (elbow), Logan Henderson (elbow), Trevor Megill (flexor strain), D.L. Hall (oblique), Jordan Montgomery (elbow), Garrett Mitchell (oblique), and Connor Thomas (elbow) all on the injured list.

The Cardinals will be without Nolan Arenado (shoulder) and Zack Thompson (lat) for this contest.

Weather

Today at American Family Field, expect mild baseball weather with temperatures around 70°F under mostly clear skies. There is a minimal chance of precipitation, so rain delays are unlikely. Winds will be light out of the southwest at 5-10 mph, creating favorable conditions for both pitchers and hitters.

In summary

The matchup between the St. Louis Cardinals and the Milwaukee Brewers at American Family Field promises an exciting clash as the Cardinals look to end their recent road skid and the Brewers aim to solidify their division lead. With favorable weather, key players returning, and both teams seeking momentum heading toward the postseason, this NL Central battle is one to watch.

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