MLB Games on Wednesday, May 4, 1910
6 games on Wednesday, May 4, 1910. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
 Chicago Cubs
3
 at Pittsburgh Pirates
8
|
Final | Game page: Chicago Cubs at Pittsburgh Pirates, Wed, May 4, 1910 |
| New York Giants 2 at Brooklyn Superbas 1 | Final | Game page: New York Giants at Brooklyn Superbas, Wed, May 4, 1910 |
| Washington Senators 2 at New York Highlanders 4 | Final | Game page: Washington Senators at New York Highlanders, Wed, May 4, 1910 |
 Cincinnati Reds
3
 at St. Louis Cardinals
12
|
Final | Game page: Cincinnati Reds at St. Louis Cardinals, Wed, May 4, 1910 |
| Cleveland Naps 3 at St. Louis Browns 3 | Final (14) | Game page: Cleveland Naps at St. Louis Browns, Wed, May 4, 1910 |
 Detroit Tigers
4
 at Chicago White Sox
0
|
Final | Game page: Detroit Tigers at Chicago White Sox, Wed, May 4, 1910 |