MLB Games on Friday, April 22, 1921
5 games on Friday, April 22, 1921. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
| Boston Braves 2 at Brooklyn Robins 4 | Final | Game page: Boston Braves at Brooklyn Robins, Fri, Apr 22, 1921 |
 Cincinnati Reds
1
 at Pittsburgh Pirates
6
|
Final | Game page: Cincinnati Reds at Pittsburgh Pirates, Fri, Apr 22, 1921 |
 New York Yankees
4
at Philadelphia Athletics
11
|
Final | Game page: New York Yankees at Philadelphia Athletics, Fri, Apr 22, 1921 |
 Philadelphia Phillies
1
at New York Giants
2
|
Final | Game page: Philadelphia Phillies at New York Giants, Fri, Apr 22, 1921 |
| St. Louis Browns 7 at Cleveland Indians 8 | Final | Game page: St. Louis Browns at Cleveland Indians, Fri, Apr 22, 1921 |