MLB Games on Wednesday, May 25, 1921
5 games on Wednesday, May 25, 1921. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
 Boston Red Sox
2
at Cleveland Indians
3
|
Final | Game page: Boston Red Sox at Cleveland Indians, Wed, May 25, 1921 |
| Chicago American Giants 7 at St. Louis Giants 6 | Final | Game page: Chicago American Giants at St. Louis Giants, Wed, May 25, 1921 |
 New York Yankees
6
at St. Louis Browns
7
|
Final | Game page: New York Yankees at St. Louis Browns, Wed, May 25, 1921 |
Philadelphia Athletics
5
 at Detroit Tigers
3
|
Final | Game page: Philadelphia Athletics at Detroit Tigers, Wed, May 25, 1921 |
Washington Senators
10
 at Chicago White Sox
5
|
Final | Game page: Washington Senators at Chicago White Sox, Wed, May 25, 1921 |