MLB Games on Wednesday, September 28, 1921
3 games on Wednesday, September 28, 1921. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
 Boston Red Sox
5
at Philadelphia Athletics
4
|
Final | Game page: Boston Red Sox at Philadelphia Athletics, Wed, Sep 28, 1921 |
| Brooklyn Robins 9 at Boston Braves 5 | Final | Game page: Brooklyn Robins at Boston Braves, Wed, Sep 28, 1921 |
 Cincinnati Reds
1
 at Chicago Cubs
3
|
Final | Game page: Cincinnati Reds at Chicago Cubs, Wed, Sep 28, 1921 |