MLB Games on Wednesday, September 21, 1927
5 games on Wednesday, September 21, 1927. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
Brooklyn Robins
2
 at Pittsburgh Pirates
4
|
Final | Game page: Brooklyn Robins at Pittsburgh Pirates, Wed, Sep 21, 1927 |
 Chicago White Sox
2
 at Boston Red Sox
3
|
Final | Game page: Chicago White Sox at Boston Red Sox, Wed, Sep 21, 1927 |
| Cleveland Indians 6 at Philadelphia Athletics 5 | Final | Game page: Cleveland Indians at Philadelphia Athletics, Wed, Sep 21, 1927 |
 Detroit Tigers
6
 at New York Yankees
1
|
Final | Game page: Detroit Tigers at New York Yankees, Wed, Sep 21, 1927 |
| St. Louis Browns 0 at Washington Senators 10 | Final | Game page: St. Louis Browns at Washington Senators, Wed, Sep 21, 1927 |