MLB Games on Wednesday, May 21, 2025

14 games on Wednesday, May 21, 2025. Start times are Eastern Time.

MLB games on Wednesday, May 21, 2025
Matchup	Status	Details
Cincinnati Reds 1 at Pittsburgh Pirates 3	Final	Game page: Cincinnati Reds at Pittsburgh Pirates, Wed, May 21, 2025
Baltimore Orioles 8 at Milwaukee Brewers 4	Final (11)	Game page: Baltimore Orioles at Milwaukee Brewers, Wed, May 21, 2025
Houston Astros 4 at Tampa Bay Rays 8	Final	Game page: Houston Astros at Tampa Bay Rays, Wed, May 21, 2025
Chicago Cubs 2 at Miami Marlins 1	Final	Game page: Chicago Cubs at Miami Marlins, Wed, May 21, 2025
Detroit Tigers 5 at St. Louis Cardinals 1	Final	Game page: Detroit Tigers at St. Louis Cardinals, Wed, May 21, 2025
Seattle Mariners 6 at Chicago White Sox 5	Final	Game page: Seattle Mariners at Chicago White Sox, Wed, May 21, 2025
Kansas City Royals 8 at San Francisco Giants 4	Final	Game page: Kansas City Royals at San Francisco Giants, Wed, May 21, 2025
Cleveland Guardians 5 at Minnesota Twins 1	Final	Game page: Cleveland Guardians at Minnesota Twins, Wed, May 21, 2025
New York Mets 5 at Boston Red Sox 1	Final	Game page: New York Mets at Boston Red Sox, Wed, May 21, 2025
Texas Rangers 3 at New York Yankees 4	Final	Game page: Texas Rangers at New York Yankees, Wed, May 21, 2025
San Diego Padres 0 at Toronto Blue Jays 14	Final	Game page: San Diego Padres at Toronto Blue Jays, Wed, May 21, 2025
Philadelphia Phillies 9 at Colorado Rockies 5	Final	Game page: Philadelphia Phillies at Colorado Rockies, Wed, May 21, 2025
Los Angeles Angels 10 at Athletics 5	Final	Game page: Los Angeles Angels at Athletics, Wed, May 21, 2025
Arizona Diamondbacks 1 at Los Angeles Dodgers 3	Final	Game page: Arizona Diamondbacks at Los Angeles Dodgers, Wed, May 21, 2025