MLB Games on Wednesday, September 21, 1910
6 games on Wednesday, September 21, 1910. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
 Chicago Cubs
1
at Brooklyn Superbas
4
|
Final | Game page: Chicago Cubs at Brooklyn Superbas, Wed, Sep 21, 1910 |
 Cincinnati Reds
11
 at Philadelphia Phillies
13
|
Final | Game page: Cincinnati Reds at Philadelphia Phillies, Wed, Sep 21, 1910 |
| Philadelphia Athletics 0 at Cleveland Naps 0 | Final (11) | Game page: Philadelphia Athletics at Cleveland Naps, Wed, Sep 21, 1910 |
 St. Louis Cardinals
5
at New York Giants
4
|
Final | Game page: St. Louis Cardinals at New York Giants, Wed, Sep 21, 1910 |
 Boston Red Sox
4
at St. Louis Browns
2
|
Final | Game page: Boston Red Sox at St. Louis Browns, Wed, Sep 21, 1910 |
New York Highlanders
4
 at Chicago White Sox
6
|
Final | Game page: New York Highlanders at Chicago White Sox, Wed, Sep 21, 1910 |