MLB Games on Wednesday, April 21, 1915
7 games on Wednesday, April 21, 1915. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
 Boston Red Sox
3
at Washington Senators
11
|
Final | Game page: Boston Red Sox at Washington Senators, Wed, Apr 21, 1915 |
| Brooklyn Robins 8 at Boston Braves 4 | Final | Game page: Brooklyn Robins at Boston Braves, Wed, Apr 21, 1915 |
 New York Yankees
8
at Philadelphia Athletics
0
|
Final | Game page: New York Yankees at Philadelphia Athletics, Wed, Apr 21, 1915 |
 Philadelphia Phillies
6
at New York Giants
1
|
Final | Game page: Philadelphia Phillies at New York Giants, Wed, Apr 21, 1915 |
 St. Louis Cardinals
0
 at Cincinnati Reds
1
|
Final (5) | Game page: St. Louis Cardinals at Cincinnati Reds, Wed, Apr 21, 1915 |
 Chicago White Sox
3
 at Detroit Tigers
4
|
Final | Game page: Chicago White Sox at Detroit Tigers, Wed, Apr 21, 1915 |
| Cleveland Indians 3 at St. Louis Browns 1 | Final (6) | Game page: Cleveland Indians at St. Louis Browns, Wed, Apr 21, 1915 |