MLB Games on Wednesday, April 21, 1926
6 games on Wednesday, April 21, 1926. Start times are Eastern Time.
| Matchup | Status | Details |
|---|---|---|
 Boston Red Sox
5
 at New York Yankees
8
|
Final | Game page: Boston Red Sox at New York Yankees, Wed, Apr 21, 1926 |
 Detroit Tigers
2
at Cleveland Indians
12
|
Final | Game page: Detroit Tigers at Cleveland Indians, Wed, Apr 21, 1926 |
 Philadelphia Phillies
1
at Boston Braves
2
|
Final | Game page: Philadelphia Phillies at Boston Braves, Wed, Apr 21, 1926 |
| Washington Senators 2 at Philadelphia Athletics 5 | Final | Game page: Washington Senators at Philadelphia Athletics, Wed, Apr 21, 1926 |
 Chicago White Sox
1
at St. Louis Browns
5
|
Final | Game page: Chicago White Sox at St. Louis Browns, Wed, Apr 21, 1926 |
 Cincinnati Reds
2
 at Chicago Cubs
4
|
Final | Game page: Cincinnati Reds at Chicago Cubs, Wed, Apr 21, 1926 |