MLB Games on Wednesday, April 22, 2026

15 games on Wednesday, April 22, 2026. Start times are Eastern Time.

MLB games on Wednesday, April 22, 2026
Matchup	Status	Details
St. Louis Cardinals 1 at Miami Marlins 4	Final	Game page: St. Louis Cardinals at Miami Marlins, Wed, Apr 22, 2026
Cincinnati Reds 1 at Tampa Bay Rays 6	Final	Game page: Cincinnati Reds at Tampa Bay Rays, Wed, Apr 22, 2026
Houston Astros 2 at Cleveland Guardians 0	Final	Game page: Houston Astros at Cleveland Guardians, Wed, Apr 22, 2026
Baltimore Orioles 8 at Kansas City Royals 6	Final	Game page: Baltimore Orioles at Kansas City Royals, Wed, Apr 22, 2026
Toronto Blue Jays 3 at Los Angeles Angels 7	Final	Game page: Toronto Blue Jays at Los Angeles Angels, Wed, Apr 22, 2026
Athletics 4 at Seattle Mariners 5	Final	Game page: Athletics at Seattle Mariners, Wed, Apr 22, 2026
Milwaukee Brewers 2 at Detroit Tigers 5	Final	Game page: Milwaukee Brewers at Detroit Tigers, Wed, Apr 22, 2026
Atlanta Braves 8 at Washington Nationals 6	Final	Game page: Atlanta Braves at Washington Nationals, Wed, Apr 22, 2026
New York Yankees 4 at Boston Red Sox 1	Final	Game page: New York Yankees at Boston Red Sox, Wed, Apr 22, 2026
Minnesota Twins 2 at New York Mets 3	Final	Game page: Minnesota Twins at New York Mets, Wed, Apr 22, 2026
Philadelphia Phillies 2 at Chicago Cubs 7	Final	Game page: Philadelphia Phillies at Chicago Cubs, Wed, Apr 22, 2026
Pittsburgh Pirates 8 at Texas Rangers 4	Final	Game page: Pittsburgh Pirates at Texas Rangers, Wed, Apr 22, 2026
San Diego Padres 3 at Colorado Rockies 8	Final	Game page: San Diego Padres at Colorado Rockies, Wed, Apr 22, 2026
Chicago White Sox 7 at Arizona Diamondbacks 11	Final	Game page: Chicago White Sox at Arizona Diamondbacks, Wed, Apr 22, 2026
Los Angeles Dodgers 0 at San Francisco Giants 3	Final	Game page: Los Angeles Dodgers at San Francisco Giants, Wed, Apr 22, 2026